Myo-inositol Scientific Studies

The effects of supplementing with myo-inositol have been investigated during the following clinical studies: 

This study's results showed that 88% of the study participants had at least one normal menstrual cycle and 72% of those women maintained normal ovulation, after the study. 40% of study participants achieved pregnancy during the 6 month study. Papaleo E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C, Marelli G, Cino I, Redaelli A, Ferrari A. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol Endocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10. PubMed PMID: 17952759. 

This study showed that plasma levels of insulin, LH and FSH were significantly reduced after 12 weeks of continued usage of myo-inositol. Insulin sensitivity was also significantly improved. For the PCOS patients who had no period or very irregular menstrual periods, menstrual cycles were restored by the end of the 12 weeks. Artini PG, Di Berardino OM, Papini F, Genazzani AD, Simi G, Ruggiero M, Cela V. Endocrine and clinical effects of myo-inositol administration in policystyc ovary syndrome. A randomized study. Gynecol Endocrinol. 2013 Jan 22. [Epub ahead of print] PubMed PMID: 23336594. 

In a comparison of myo-inositol and D-chiro-inositol, this study showed that only myo-inositol was able to improve oocyte and embryo quality. Galletta M, Grasso S, Vaiarelli A, Roseff SJ. Bye-bye chiro-inositol - myo-inositol: true progress in the treatment of polycystic ovary syndrome and ovulation induction. Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1212-4. PubMed PMID: 22165685. 

"These data suggest that myoinositol may be useful in the treatment of PCOS patients undergoing ovulation induction, both for its insulin-sensitizing activity, and its role in oocyte maturation."  

Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. 2011 May;15(5):509-14. PubMed PMID: 21744744.