Clomiphene citrate, popularly known as Clomid, is one of the most successful fertility medications available today. Clomid is also one of the least expensive fertility treatments available and is usually the first medication prescribed. Unfortunately, Clomid does not work for everyone; with some women experiencing a variety of side effects.

What Does Clomid Do?

According to WebMD, Clomid is used for the stimulation of hormones that are required for successful ovulation. Administered within a period of five consecutive days, for a period ranging between three and six months, it could take multiple cycles for an effective dose of Clomid to be determined.  Once that dose has been determined, Clomid is prescribed for a further three cycles. If conception has not occurred after taking Clomid for 6 cycles, it is then deemed unsuccessful.

How Does Clomid Work?

Clomid can work in the assistance of successful conception in several ways. Firstly, Clomid stimulates ovulation in women who previously failed to ovulate on their own. It may also regulate ovulation in women who had irregular ovulatory cycles. Clomid does this by influencing estrogen receptors, such as the vagina, cervix, endometrium, pituitary gland, ovaries, and hypothalamus.

Secondly, Clomid can also serve as an ovarian reserve evaluation tool. Prescribed at the initial stage of a woman’s menstruation cycle, Clomid elevates a woman’s Follicle Stimulating Hormone (FSH). The following day, a blood test will be taken and if there is a drop in FSH then this is seen as a sign that a woman has normal ovarian reserve and that ovulation occurs. However a higher than normal FSH level would depict a low ovarian reserve. Thirdly, Clomid plays the functional role of stimulating the development of multiple eggs, by fooling the body into thinking that estrogen is low. This causes the release of more GnRH, which in turn prompts the creation of more LH and FS – and this encourages the release of one or more mature eggs.

It is not true that Clomid is for women alone, Clomid can also be prescribed to men to help treat low sperm count.

How Then Does Clomid Affect Conception Success Rates?

  1. Ovulation Stimulation
  2. Clomid is designed to stimulate ovulation. Conception can only take place after ovulation has occurred. It is crucial that the ovaries release a mature egg into the fallopian tube so that sperm can fertilize it. It is only upon successful ovulation that conception can occur.

  3. Ovulation Regulation
  4. Clomid is also administered to regulate a woman’s ovulatory cycle. With this, monthly attempts at conception will most likely yield success.

  5. Multiple follicle development
  6. With the multiple follicle development that Clomid offers, the chances of sperm finding more than one egg to fertilize are higher and conception success rates rise.

  7. Higher sperm count
  8. For a male partner whose sperm count is too low to achieve successful fertilization of the female egg, Clomid raises the sperm count to be strong enough for conception to occur.

Clomid Success Rates

According to the American Society for Reproductive Medicine’s Medications for Inducing Ovulation 80 percent of patients will achieve successful ovulation with Clomid, and approximately 40 to 45 percent of these women will become pregnant within six cycles after starting on Clomid. Statistics also vary between one fertility clinic and another or one fertility specialist to another. If there are no other fertility problems, the success rate of couple conceiving while taking Clomid is between 10 and 20 percent – which is on par with other fertile couples.