What are the Conception Success Rates when Using Clomid?

Clomiphene citrate, popularly known as Clomid, is one of the most successful fertility medications available today. Clomid is also one of the least expensive fertility treatments available and is usually the first medication prescribed. Unfortunately, Clomid does not work for everyone; with some women experiencing a variety of side effects.

What Does Clomid Do?

According to WebMD, Clomid is used for the stimulation of hormones that are required for successful ovulation. Administered within a period of five consecutive days, for a period ranging between three and six months, it could take multiple cycles for an effective dose of Clomid to be determined.  Once that dose has been determined, Clomid is prescribed for a further three cycles. If conception has not occurred after taking Clomid for 6 cycles, it is then deemed unsuccessful.

How Does Clomid Work?

Clomid can work in the assistance of successful conception in several ways. Firstly, Clomid stimulates ovulation in women who previously failed to ovulate on their own. It may also regulate ovulation in women who had irregular ovulatory cycles. Clomid does this by influencing estrogen receptors, such as the vagina, cervix, endometrium, pituitary gland, ovaries, and hypothalamus.

Secondly, Clomid can also serve as an ovarian reserve evaluation tool. Prescribed at the initial stage of a woman’s menstruation cycle, Clomid elevates a woman’s Follicle Stimulating Hormone (FSH). The following day, a blood test will be taken and if there is a drop in FSH then this is seen as a sign that a woman has normal ovarian reserve and that ovulation occurs. However a higher than normal FSH level would depict a low ovarian reserve. Thirdly, Clomid plays the functional role of stimulating the development of multiple eggs, by fooling the body into thinking that estrogen is low. This causes the release of more GnRH, which in turn prompts the creation of more LH and FS – and this encourages the release of one or more mature eggs.

It is not true that Clomid is for women alone, Clomid can also be prescribed to men to help treat low sperm count.

How Then Does Clomid Affect Conception Success Rates?

  1. Ovulation Stimulation
  2. Clomid is designed to stimulate ovulation. Conception can only take place after ovulation has occurred. It is crucial that the ovaries release a mature egg into the fallopian tube so that sperm can fertilize it. It is only upon successful ovulation that conception can occur.

  3. Ovulation Regulation
  4. Clomid is also administered to regulate a woman’s ovulatory cycle. With this, monthly attempts at conception will most likely yield success.

  5. Multiple follicle development
  6. With the multiple follicle development that Clomid offers, the chances of sperm finding more than one egg to fertilize are higher and conception success rates rise.

  7. Higher sperm count
  8. For a male partner whose sperm count is too low to achieve successful fertilization of the female egg, Clomid raises the sperm count to be strong enough for conception to occur.

Clomid Success Rates

According to the American Society for Reproductive Medicine’s Medications for Inducing Ovulation 80 percent of patients will achieve successful ovulation with Clomid, and approximately 40 to 45 percent of these women will become pregnant within six cycles after starting on Clomid. Statistics also vary between one fertility clinic and another or one fertility specialist to another. If there are no other fertility problems, the success rate of couple conceiving while taking Clomid is between 10 and 20 percent – which is on par with other fertile couples.

  • Pixy

    well, i am on my 6th cycle. i hope it works! been trying 2 years and without clomid i have anovulatory cycles…

    • earthsmagic

      Good luck Pixy! Do the doctors know what is causing yoru anovulatory cycles? If it is due to PCOS you might want to have a look at Pregnitude It has a pretty good record of restoring ovulation / cycles in women with PCOS. Of course, don’t take it unless you talk to your doctor about it first.

  • Aisha lovely

    i am very excited, my doctor want me to start it on my next cycle been trying to conceive for four years without Clomid. hope it works…

    • Laura

      I am about to try Clomid for the first time as well, after 4 years of zero conception. Fingers crossed… Good luck to you!

      • Kim

        Am starting clomid tmrw.. Fingers crossed !! Hoping for the best for all of us. Good luck guys :]

  • Sherrika BELLAMY

    On my 3rd dose of Clomid. Just increase to 150 mg. Hubby and I am praying this works. We can not afford IVF! Keep us in your prayers.

  • kingsqueen

    Diagnosed with PCOS and just finished my first round of clomid. Have been trying to conceive for many years. I also am unable to afford IVF. Pray for us please.

    • Nikki1979

      I’m on my 1st cycle after trying for one year, after beating cervical cancer. I’m on 50mg, should have ovulated by now, but no LH surge… It’s so hard. It’s devastating to see newborns everywhere and just feeling sad all the time! Fingers crossed

  • Rachael Moore

    Hi my husband and I are trying to get pregnant and we can’t afford ivf and I have very irregular periods we are currently taking proved a and then Clomid we have only been trying for 6 months but we want a family so bad please keep your fingers crossed that this works for us its very frustrating any advice on Clomid and provera? Never done this before

    • Angel Sickmeier

      You’re lucky. My dr wouldn’t prescribe clomid for me until we had been trying for a year. Starting my first cycle tomorrow. Fingers crossed for a positive pregnancy test and a healthy baby for all!

    • D

      I’m gonna be starting the same as you I hope you are doing well, I wish u the best!

  • Dar

    Gonna be starting clomid for a second time, TTC since I was 25yrs old, I am now 33 and Gina give it al I got this time!! Prayers to all xoxox hoping for the best for us!

Last modified: June 3, 2014